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| The progress of abnormal expression of Lutheran blood group glycoprotein in cancers |
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| DOI：10.46701/BG.2020012020105 |
| KeyWord:Lutheran blood group, glycoprotein, laminin, cancer |
| Author | Institution |
| Hua Wei |
Department of Blood Transfusion, Tangdu Hospital, the Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China. |
| Ying Cui |
Department of Blood Transfusion, Tangdu Hospital, the Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China. |
| Yang Chen |
Department of Blood Transfusion, Tangdu Hospital, the Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China. |
| Shijie Mu |
Department of Blood Transfusion, Tangdu Hospital, the Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China. |
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| Abstract: |
| Lutheran blood group glycoprotein (Lu-gp) is a specific α5 laminin receptor that is linked by binding to its receptor in the basement membrane matrix. Although the biological function of Lu-gp is unknown, its special affinity with laminin in the chain suggests that it plays an important role in human development and physiological
processes. As the interaction between Lu-gp and laminin is further investigated, their expression may be found to
play an important role in tumor invasion and metastasis. Laminin receptors help cells adhere, receive and conduct
extracellular information into cells, mainly through MAPK pathways, including ERKs, p38MAPK, etc., affecting
the degradation of the extracellular matrix and enhancing tumor cell infiltration and metastasis. Present researches
in cancers mainly focus on aspects relating to laminin, but largely do not pay attention to the Lutheran blood group antigen, basal cell adhesion molecule. This paper focuses on the abnormal expression of the laminin receptor, that is, the Lutheran blood group antigen, in cancers, which is of great significance to the mechanism of cancer invasion and metastasis, and for finding effective treatment methods for cancers. |
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