Incidence of piperacillin-specific drug antibody in patients with and without piperacillin
  
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KeyWord:piperacillin-specific drug antibody, piperacillin sensitized RBC, drug safety
                             
AuthorInstitution
Zhiwei Liu Department of Blood Transfusion, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, China;
Zhen Cheng International Healthcare Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, China;
Na Ma Department of Blood Transfusion, Cancer Hospital of Yunnan Province, Kunming 650106,Yunnan,China;
Bao-lan Hao Blood?Transfusion?Department, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, Henan, China;
Dan Xu Jiangsu LIBO Medicine Biotechnology Co., Ltd., Jiangyin 214434, Jiangsu, China;
Yetao Han Department of Blood Transfusion, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, China;
Mengsi Hu Department of Blood Transfusion, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, China;
Rui Wang Department of Blood Transfusion, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, China;
Daowang Fan Blood?Group?Lab, Beijing?Red?Cross?Blood?Center, Beijing?100088, China;
Meiying Rao Department of Blood Transfusion, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
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Abstract:
      The aim of this study was to investigate the incidence of piperacillin-specific drug antibody in patients with and without piperacillin. Piperacillin antibody was detected by piperacillin-induced hemolysis test kit. Three hundred samples were collected from patients who had been treated with piperacillin within 3 months; and 222 samples were from patients who were treated with other antibiotics; and a normal group of 120 samples was from healthy blood donors. The results showed that the positive rates in the piperacillin group, the other antibiotic group and the control group were 11.33%, 4.95% and 1.67%, respectively, which was statistically significant. The antibody titer was from 2 to 64. The antibody titer of the piperacillin group was significantly higher than that of the other two groups. The study suggests that piperacillin is able to induce piperacillin-specific drug antibody and drug antibody detection is useful for maintaining the safety of medication.
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