Establishment of laboratory quality control indicators for NAT on blood donors' samples
  
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KeyWord:NAT, invalid results, quality control indicator, Possion distribution, quality control chart
              
AuthorInstitution
Ziyi He Department of Transfusion Research, Dongguan Blood Center, Dongguan, Guangdong, 523930, China
Shaobin Chen Department of Transfusion Research, Dongguan Blood Center, Dongguan, Guangdong, 523930, China
Lin Yu Department of Transfusion Research, Dongguan Blood Center, Dongguan, Guangdong, 523930, China
Qing Wang Department of Transfusion Research, Dongguan Blood Center, Dongguan, Guangdong, 523930, China
Jiaoli Zou Department of Transfusion Research, Dongguan Blood Center, Dongguan, Guangdong, 523930, China
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Abstract:
      In order to establish and screen nucleic acid test (NAT) quality control indicators for blood donor samples, CT value of each test item were detected by NAT, internal and external quality controls, the number of unsuccessful mixed samples, the split positive rate, the rate of detection efficiency, and the equipment failure rate were collected. The "instant method" is used to establish the Levey-Jennings quality control chart, the mixed test positive rate, the rate of unqualified sample. Possion distribution is used to establish the quality control chart, and it is easily to operate and monitor NAT effectively. The results displayed that quality control charts were established, including unqualified sample Possion distribution quality control chart, the rate of equipment failure quality control chart, the failure rate of reagent batch and inefficient quality control chart, test result positive of Possion distribution quality control chart, quality control charts of NAT positive Possion distribution probability, the rate of split positive quality control charts, quality control charts of unsuccessful mixed samples, quality control chart of reagents effective rate, internal quality control chart, correctness, and NAT qualitative quality control chart. The study established quality control indicators throughout the whole NAT process, which were able to effectively improve NAT quality control and the efficacy of laboratory management.
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