Coagulation status detection in breast cancer patients by using thrombelastography
  
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KeyWord:breast cancer, thrombelastography, coagulation, hypercoagulability, venous thromboembolism
              
AuthorInstitution
Baolan Hao Blood?Transfusion?Department, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008,China;
Hengwei Zhang Department of Breast Diseases, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008,China.
Yu-ping Ye Blood?Transfusion?Department, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008,China;
Xinjian Hao Blood?Transfusion?Department, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008,China;
Yan Wang Blood?Transfusion?Department, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008,China.
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Abstract:
      Many cancer patients are known to present in a hypercoagulable state, meaning an increased risk of thrombosis. To investigate hypercoagulable state in breast cancer (BC) patients, their coagulation status was compared with a benign disease group (control). The BC patients were divided into earlier stage (stage I and stage Ⅱ ) and later stage (stage Ⅲ and stage Ⅳ ). Thrombelastography (TEG) and other traditional coagulation tests were performed. The results showed that prothrombin time (PT) was significantly shortened and the levels of D-dimer, fibrinogen (Fib) and platelets (PLT) were significantly increased in the traditional BC group test (P< 0.05). According to TEG detection, the average level of blood clot formation time (K) was significantly lower, while the Angle, MA and CI were significantly higher in the BC group than those in benign disease group (P< 0.05). There were 5 cases of lower extremity venous thrombosis in the breast cancer patients, coinciding with hypercoagulable state. The results showed that the BC patients had an increased hypercoagulable state, with hypercoagulability becoming more obvious in advanced stages. This study suggests that BC patients have an increased tendency for clot formation, and TEG monitoring could be a useful tool to predict the risk of thrombosis for clinical prevention and treatment.
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