A dynamic analysis of viral load, T lymphocyte subsets and main biochemical indexes before and after prevention of mother to child transmission (PMTCT) in HIV/AIDS
  
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KeyWord:HIV/AIDS, mother to child transmission (PMTCT), viral load, T lymphocyte subsets count, main biochemical indexes.
           
AuthorInstitution
Guosheng Su Department of Clinical Laboratory,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong,China; Department of Orthopedics, the Hospital of Traditional Chinese and Western Medicine of Guangxi Guigang City, Guigang Red Cross Hospital, Guigang 537100, Guangxi, China.
Yesheng Wei Department of Clinical Laboratory, the First Affiliated Hspital of Guilin Medical College, Guilin 541000, Guangxi, China.
Lihua Qin Department of Osteoarthritis Nursing and Department of Orthopedics, the Hospital of Traditional Chinese and Western Medicine of Guangxi Guigang City, Guigang Red Cross Hospital, Guigang 537100, Guangxi, China.
Lida Mo Department of Clinical Laboratory, Nanning Fourth People's Hospital,Nanning Infectious Diseases Hospital Affiliated to Guangxi Medical University,Guangxi AIDS Clinical Treatment Center, Nanning 530023, Guangxi, China.
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Abstract:
      This study aims to investigate changes in viral load, T lymphocyte subsets and other main biochemical indexes of HIV/AIDS in the prevention of mother to child transmission (PMTCT). In this study, 152 pregnant women with HIV/AIDS enrolled into our hospital from January 2013 to June 2015 were chosen as objects. Changes in viral load, T lymphocyte subsets and other main biochemical indexes of HIV/AIDS were tested and compared before and after 3 months of PMTCT and in neonatals one week after birth. The CD4/CD8 examination result, and difference in CD4 before and after prevention (in the newborns after a week) was statistically significant (P < 0.05), and the rest showed no statistical significance. For the dynamic analysis of main biochemical test results: K+, Na+, Cl-, BG, OS, BUN, BUN/Cr, UA,TDIL, DBIL, TP, ALB, CK, LDH, HDL, LDL and other indexes before and after prevention attained statistical significances (P < 0.05 or above). The same sample in the three groups was detected by repeated analysis of variance, K+, Na+, Cl-, BG, OS, BUN/Cr, UA, DBI L, ALB, CK, LDH, HDL, LDL and other indexes also showing P at less than 0.05 or above, among which K+, Cl-, CK, LDL showed homogeneity of variance, while Na+, BG, OS, BUN/Cr, UA, DBIL, ALB, LDH, HDL showed unequal homogeneity of variance. The study suggests that the dynamic analysis of viral load, T lymphocyte subsets and main biochemical indexes before and after PMTCT in HIV/AIDS are important means to evaluate the dose and treatment of antiretroviral drugs. Monitoring of above indexes is helpful to judge and analyze the condition of the maternal body at various stages, so antiviral drug treatment can be adjusted.
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