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| Role of HLA DRB1*15 and HLA DRB1*16alleles in the genetic susceptibility to develop systemic lupus erythematosus (SLE) after Chikungunya and Zika viruses infection in México |
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| DOI：10.46701/APJBG.2018042018127 |
| KeyWord:systemic lupus erythematosus, HLA antigens, Chikungunya virus, Zika virus, genetic susceptibility |
| Author | Institution |
| Sepúlveda-Delgado J |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Danis-Lozano R |
Regional Center of Public Health Research of National Institute of Public Health, Tapachula, Chiapas, Mexico; |
| Ocaa-Sibilla MJ |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Ramirez-Valdespino JC |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Cetina-Díaz JH |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Bulos-Rodriguez P |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Hernández-Doo S |
Department of Transplants and Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México; |
| Ruiz-Gómez D |
Department of Transplants and Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México; |
| García R |
Department of Transplants and Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México; |
| Juárez-Nicolás F |
Department of Transplants and Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México; |
| Tevera-Gamboa MG |
Hematology Department, Hospital General de Zona #1 IMSS, Tapachula, Chiapas, México; |
| Vera-Lastra OL |
Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico a Raza, CDMX,México; |
| Jara LJ |
Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico a Raza, CDMX,México; |
| Canseco-Avila LM |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Dominguez-Arrevillaga S |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Trujillo-Murillo K |
Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, México; |
| Julio Granados J |
Department of Transplants and Immunogenetics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México; |
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| Abstract: |
| Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous disease particularly prevalent in Mexico. Althoughits etiology is unknown, genetic factors strongly influence its presenceas well as triggering factors, such as viral infections, including Cytomegalovirus and Epstein-Barr virus. Here,the study presents the appearance of de novoSLE (patients who did not present SLE before de virus infection, corroborated by serological analysis and negative for antinuclear antibodies) cases in Mexicans who live near the southern border of Mexico, who presented clinical symptoms of arthritic, hematological, mucocutaneous and renal SLE, after Zika and/ or Chikungunya virus infection. Low resolution class Ⅱ HLA typing was performed, which found a significantly increased frequency of HLA DRB1*02 (15 and 16)when compared to a group of 99 healthy individuals (P =0.001, OR=4.5, IC95% 1.8~11.0). All the patients were diagnosed with SLE 1 to 3 years after being confirmed with the Zika, and/or Chikungunya infection. At the point of acute viral infection, none of the patients presented clinical signs or symptoms of autoimmunity or were negative for antinuclear antibodies. In genetically susceptible individuals, Zika and Chikungunya viral infection can trigger SLE. |
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