HLA class Ⅱ alleles in human sporotrichosis in Mexican Amerindians
  
View Full Text  View/Add Comment  Download reader
DOI:10.46701/APJBG.2018032018119
KeyWord:sporotrichosis, HLA class Ⅱ , DR4, DR4 subtypes, DR*0401, DR8, Mexican mestizo
                       
AuthorInstitution
Guadalupe E. Estrada-Chávez Dermatology Department, General Hospital de Acapulco, Guerrero, México
Roberto Estrada Medicine Faculty, Universidad Autónoma de Guerrero, México
Guadalupe Chavez Dermatology Department, General Hospital de Acapulco, Guerrero, México
María-Elisa Vega Memije Dermatology Department, General Hospital Dr. Manuel Gea González, Mexico City, México
Roberto Arenas Guzmán Medical Mycology Department, General Hospital Dr. Manuel Gea González, Mexico City, México.
Maricela García-Lechuga Department of Transplantation, Inmunogenetics, Instituto Nacional de Ciencias Médicas y de la Nutrición, Salvador Zubirán, México
Julio Granados Department of Transplantation, Inmunogenetics, Instituto Nacional de Ciencias M édicas y de la Nutrición, Salvador Zubirán, México
Lucia Rangel-Gamboa Division of Investigation, General Hospital Dr. Manuel Gea González. Mexico City, México
Hits: 2416
Download times: 1968
Abstract:
      Human leukocyte antigen (HLA) class Ⅱ alleles are involved in antigen processing and presentation to T lymphocytes during fungal infections. However, few studies have investigated HLA genes in fungal diseases, or in sporotrichosis infections. Here, the frequencies of HLA-DRβ1 in 50 healthy volunteers and 9 patients with sporotrichosis from an endemic area in Mexico were determined to define their role in genetic susceptibility to this infection. Also, the frequencies of HLA-DRβ1 haplotypes were compared with a historic control group of healthy Mexican individuals. The patients presented that DR4 and DR8 increased, which were more than twice the control's values, whereas local controls (endemic area) presented DR*04:01 increased, compared with the control group from Mexico City. The data suggest that involvement of HLA antigens could affect the outcomes of the host-fungi interaction in sporotrichosis by regulating the immune response to Sporothrix schenckii complex.
Close