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HLA class Ⅱ alleles in human sporotrichosis in Mexican Amerindians |
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DOI:10.46701/APJBG.2018032018119 |
KeyWord:sporotrichosis, HLA class Ⅱ , DR4, DR4 subtypes, DR*0401, DR8, Mexican mestizo |
Author | Institution |
Guadalupe E. Estrada-Chávez |
Dermatology Department, General Hospital de Acapulco, Guerrero, México |
Roberto Estrada |
Medicine Faculty, Universidad Autónoma de Guerrero, México |
Guadalupe Chavez |
Dermatology Department, General Hospital de Acapulco, Guerrero, México |
María-Elisa Vega Memije |
Dermatology Department, General Hospital Dr. Manuel Gea González, Mexico City, México |
Roberto Arenas Guzmán |
Medical Mycology Department, General Hospital Dr. Manuel Gea González, Mexico City, México. |
Maricela García-Lechuga |
Department of Transplantation, Inmunogenetics, Instituto Nacional de Ciencias Médicas y de la Nutrición, Salvador Zubirán, México |
Julio Granados |
Department of Transplantation, Inmunogenetics, Instituto Nacional de Ciencias M édicas y de la Nutrición, Salvador Zubirán, México |
Lucia Rangel-Gamboa |
Division of Investigation, General Hospital Dr. Manuel Gea González. Mexico City, México |
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Abstract: |
Human leukocyte antigen (HLA) class Ⅱ alleles are involved in antigen processing and presentation to T
lymphocytes during fungal infections. However, few studies have investigated HLA genes in fungal diseases, or in sporotrichosis infections. Here, the frequencies of HLA-DRβ1 in 50 healthy volunteers and 9 patients with sporotrichosis from an endemic area in Mexico were determined to define their role in genetic susceptibility to this infection. Also, the frequencies of HLA-DRβ1 haplotypes were compared with a historic control group of healthy Mexican individuals. The patients presented that DR4 and DR8 increased, which were more than twice the control's values, whereas local controls (endemic area) presented DR*04:01 increased, compared with the control group from Mexico City. The data suggest that involvement of HLA antigens could affect the outcomes of the host-fungi interaction in sporotrichosis by regulating the immune response to Sporothrix schenckii complex. |
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