Frequencies of RhCE and Kell phenotypes in Xinjiang using a cross-minorities transfusion simulation model
  
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KeyWord:Kell(K) blood type, Rh(CE) blood type, Uyghur, Kazak, antigen distribution
                 
AuthorInstitution
Wei Chen Department of Blood Transfusion, Xinjiang Uyghur Autonomous People′s Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830001, China
Jun Wen Department of Blood Transfusion, Xinjiang Uyghur Autonomous People′s Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830001, China
Fei Li Department of Blood Transfusion, Xinjiang Uyghur Autonomous People′s Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830001, China
Changmin Wang Clinincal Laboratory, Xinjiang Uyghur Autonomous People′s Hospital, Urumqi, Xinjiang, 830001,China
Qing Li Department of Blood Transfusion, Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical Uninersity, Urumqi, Xinjiang, 834000, China
Gang Zhao Department of Blood Transfusion, Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical Uninersity, Urumqi, Xinjiang, 834000, China
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Abstract:
      Xinjiang represents one of the richest minorities’ areas in China. This high ethnic diversity reflects in the blood groups and immune status and has a consequent impact on blood transfusions. To evaluate the risks of cross-minority transfusion in Xinjiang, we investigated the frequencies of erythrocytic Rh and K antigens among 1,073 Uyghurs and 213 Kazaks. We further reviewed the literature on the frequency of erythrocytic antigens to develop a simulation model for calculating the risk of patients in Xinjiang exposed to mismatched erythrocytic antigens. The frequencies of RhE, RhC, and K phenotypes were as follows: C antigen, 52.3% in Uyghurs and 56.8% in Kazaks; c antigen, 47.7% in Uyghurs and 43.2% in Kazaks; E antigen, 25.5% in Uyghurs and 27.2% in Kazaks; e antigen, 74.5% in Uyghurs and 72.8% in Kazaks; K antigen, 1.8% in Uyghurs and 1.8% in Kazaks. The population-adjusted cumulative match rate demonstrated that 53.3%, 51.4%, 50.6%, and 53.7% of the Uyghur, Kazak, Han, and Hui populations were recipients, respectively, although the recipients were transfused with an unknown Rh blood type. We concluded that the risks of cross-minority transfusion in Xinjiang are insignificant. The best strategy appears to be K and Rh-matched transfusions in this region due to the much higher frequency of the K antigen compared to other areas in China.
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